Aebersold, Mathias

Unraveling how billions of nerve cells in the human brain work together and carry out their functions from processing sensory signals to storing information is one of the key challenges of this century. I am interested in developing methods to engineer and study networks of neurons in a petri dish. 

Research interests

• Stimulation of neuronal cultures
• Engineered neuronal networks
• FluidFM technology

Publications

• external page “Brains on a chip”: Towards engineered neural networks
  M. J. Aebersold, H. Dermutz, C. Forró, S. Weydert, G. Thompson-Steckel, J. Vörös, L. Demkó
  Trends in Analytical Chemistry (2016) DOI: 10.1016/j.trac.2016.01.025
• external page Controlled single-cell deposition and patterning by highly flexible hollow cantilevers
  V. Martinez, C. Forró, S. Weydert , M. J. Aebersold, H. Dermutz, O. Guillaume-Gentil, T. Zambelli, J. Voros, L. Demkó
  Lab on a Chip (2016) DOI: 10.1039/C5LC01466B
• external page Easy to Apply Polyoxazoline-Based Coating for Precise and Long-Term Control of Neural Patterns 
  S. Weydert, S. Zürcher, S. Tanner, N. Zhang, R. Ritter, T. Peter, M. J. Aebersold, G. Thompson-Steckel, C.  Forró, M. Rottmar, F.  Stauffer, I.A. Valassina, G. Morgese, E.M. Benetti, S. Tosatti, J. Vörös
  Langmuir (2017) DOI: 10.1021/acs.langmuir.7b01437
• external page Local Chemical Stimulation of Neurons with the FluidFM 
  M. J. Aebersold, H. Dermutz, L. Demkó, J.F. Saenz Cogollo, S.-C. Lin, C. Burchert, M. Schneider, D. Ling, C. Forró, H. Han, T. Zambelli, J. Vörös 
  ChemPhysChem (2017) DOI: 10.1002/cphc.201700780

Oral Presentations

• Stimulating neuronal cultures by local release of neurotransmitters using the FluidFM as a forcecontrolled nanopipette combined with MEAs for electrical activity recording
  H. Dermutz, J. F. Saenz Cogollo, M. J. Aebersold, L. Demkó, T. Zambelli, J. Vörös
  UK SPM, 26-27 June 2013, Leeds, UK
• Combining FluidFM and microelectrodes arrays for single-neuron stimulation
  M. J. Aebersold, H. Dermutz, J. F. Saenz Cogollo, L. Demkó, T. Zambelli, J. Vörös
  3rd FluidFM European Workshop, 25 May 2014, Liestal, Switzerland
• Liquid flow characterization of the FluidFM – how much chemicals do I really have at the tip?
  M. J. Aebersold, T. Zambelli, J. Vörös
  5th Flex-FPM & FluidFM User Meeting, 4 July 2016, Würzburg, Germany

Poster Presentations

• Localized chemical stimulation and mapping of neuronal cultures combining FluidFM with MEA
  H. Dermutz, M. J. Aebersold, J. F. Saenz Cogollo, L. Demkó, T. Zambelli, J. Vörös
  SfN Neuroscience 2013, 9-13 November 2013, San Diego, CA, USA
• Chemical Stimulation of Single Neurons in an in vitro System: Coupling a Force-Controlled Nanopipette with a MEA Recording System
  H. Dermutz, M. J. Aebersold, J. F. Saenz Cogollo, L. Demkó, T. Zambelli, J. Vörös
  6th international IEEE EMBS Neural Engineering Conference, 6-8 November 2013, San Diego, CA, USA
• Subcellular chemical stimulation of neuronal cultures using the FluidFM nanopipette combined with MEA recording
  H. Dermutz, M. J. Aebersold, J. F. Saenz Cogollo, L. Demkó, T. Zambelli, J. Vörös
  9th FENS Forum of Neuroscience, 5-9 July 2014, Milan, Italy
• Connecting neurons using FluidFM technology: Towards engineered neuronal networks
  M. J. Aebersold, T. Zambelli, J. Vörös
  NanoBioTech 2014, 17-19 November 2014, Montreux, Switzerland
• Using the FluidFM to connect neurons, a step towards building engineered networks
  M. J. Aebersold, T. Zambelli, J. Vörös
  6th AFMBioMed Conference, 13 - 17 December 2014, San Diego, CA, USA
• Engineered neuronal networks – Connecting, stimulating, and recording neurons
  M. J. Aebersold, H. Dermutz, J. F. Saenz Cogollo, L. Demkó, T. Zambelli, J. Vörös
  Swiss Society for Neuroscience Annual Meeting 2015, 24 January 2015, Fribourg, Switzerland
• Local chemical stimulation of neurons using FluidFM technology combined with microelectrode arrays
  M. J. Aebersold, H. Dermutz, J. F. Saenz Cogollo, L. Demkó, H. Han, T. Zambelli, J.Vörös
  MicroTAS 2015, 25-29 October 2015, Gyeongju, South Korea

Education

• MSc Biomedical Engineering, ETH Zürich
• BSc Electrical Engineering and Information Technology, ETH Zürich

Students Projects

• Manual multichannel pressure controller and pressure sensor
  Alejandro Sancho Puchades (Visiting student 2014)
• Neuronal networks on microcontact printed patterns
  Trang Le (AMGEN scholarship 2015)
• Automated activity analysis of neuronal cultures (neurons.ee.ethz.ch)
  Conrad Burchert & Moritz Schneider (ETH Semester Thesis 2016)
• Cellulose-based 3D coculture promoting healthier low-density neuronal cultures
  Adriane Joutang (Université Grenoble Alpes Master Thesis 2016)
• Adapter for multichannel microuidic AFM cantilevers
  Haoyang Cui (ETH Bachelor Thesis 2016)
• Analysis of patterned networks of neurons
  Lina Hacker (RTWH Aachen, internship 2016)